What causes Tay-Sachs disease?
Tay-Sachs disease is caused by a mutation in the HEXA gene. A genetic mutation is a permanent alteration in the DNA sequence that makes up a gene. It causes one or more processes of the body to not work properly.
A mutated HEXA gene results in the body not producing an enzyme called Hexosaminidase-A (Hex-A). Without this enzyme, a fatty substance called GM2 ganglioside builds up in the cells of the brain and nerves, and stops them working normally, eventually destroying them.
Both parents have to be carriers of a HEXA mutation to be at risk of having a child with Tay-Sachs disease. If both parents are carriers, their children will have a 25% chance of developing the condition.
http://www.nhs.uk/conditions/Tay-Sachs-disease/Pages/Introduction.aspx
Did Adam's sin also cause genetic mutations? Or did the Guy who designed DNA cause them?